The composition of raw milk is important for the stability of dairy products with a long shelf-life. Based on known historical changes in raw milk composition, the aim of this study was to get a better understanding of how possible future variations in milk composition may affect the stability of dairy products.

The results showed that elevated level of calcium lowered the pH, resulting in sedimentation and significantly decreased stability. Elevated level of citrate was associated with color, but the stability was not improved compared to the reference UHT milk. Elevated levels of urea or interaction terms had little effect on the stability of UHT milk.

Storage conditions significantly affected the stability. In conclusion, to continue produce dairy products with high stability, the dairy industry should make sure the calcium content of raw milk is not too high and that storage of the final product is appropriate.

The composition and properties of raw milk are important for the manufacture of ultra-high temperature UHT treated milk to ensure a final product with high stability during storage, meeting the expected shelf-life. Low stability can lead to fat separation, sedimentation, gelation, and browning [ 1 ]. Parameters considered to have most influence on the stability of UHT milk include protein composition, ionic calcium content, pH and parameters affecting all of these [ 2 ].

Calcium is important for the internal structure and stability of the casein micelle, both via the colloidal calcium phosphate associated to casein molecules and by the formation of calcium bridges between negatively charged residues of the caseins [ 34 ]. In milk serum, calcium can form complexes with other agents, or exists as free ions. Total calcium content in milk has been reported at average levels of 26—32 mM [ 5 ].

Judge Dredd

The calcium equilibria between the colloidal and serum phase is affected by pH, and a reduction in pH will increase the calcium ion concentration in the milk serum [ 36 ]. Also, temperature affects the calcium equilibria. When milk is stored at refrigerated temperatures, calcium phosphate will dissolve, whereas at higher temperatures, calcium phosphate will migrate into the micelle [ 7 ]. Previous studies comparing different calcium salts, i.

Citrate, mainly present in milk serum, plays an important role in the mineral equilibria of milk and is part of a buffering system between calcium and hydrogen ions. Citrate improves the stability of the milk by forming soluble complexes with calcium, preventing precipitation of calcium phosphate [ 10 ].

High levels of citrate have been shown to increase calcium levels in milk serum and consequently a depletion of the colloidal calcium in the casein micelles [ 4 ].

cit-cal

The average value of citrate in milk is 7—11 mM [ 5 ], varying significantly with feed and stage of lactation [ 1112 ]. Milk urea is known to vary with stage of lactation, season, and feed [ 131415 ]. A higher concentration of urea acts as a stabilizing agent on the micelle [ 16 ]. It has been suggested that elevated levels of urea prevent crosslinking and aggregation of proteins, and also keep the pH stable [ 2 ]. An average urea level of 4. The stability of the milk can be evaluated by sensory attributes, including fat separation, fat adhesion to the packaging material, sediment formation, and color, varying with storage time and temperature [ 19 ].

During storage of UHT milk, fat globules float to the top, resulting in fat separation and fat adhesion [ 1 ]. Fat separation is closely correlated to and will increase with fat content, storage temperature, and milk fat globule size [ 2021 ]. In UHT products, sediment formation is also a well-known problem. It is suggested that sediment consists of aggregates of proteins or protein particles of various sizes [ 22 ].

Casein micelles can, by the influence of gravity, sediment under their own weight [ 23 ]. Aggregation of micelles will further increase the rate of sedimentation [ 23 ]. Sediment formation has also been shown to increase with storage temperature [ 122 ]. During storage change in the color of UHT milk is mainly affected by the Maillard reaction, resulting in the formation of brown pigments in milk stored at warm temperatures [ 24 ].You can request verification for native languages by completing a simple application that takes only a couple of minutes.

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Became a member: Sep X Sign in to your ProZ. Username: Password: Forgot your password?Important Notice: The Drugs. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Subscribe to our newsletters. FDA Safety Alerts. Daily MedNews. Weekly Drug News Roundup. Monthly Newsletter. I accept the Terms and Privacy Policy. Select one or more newsletters to continue. Email address. Explore Apps. About About Drugs. All rights reserved.Judge Dredd is a comic book franchise based on the longest-running comic strip in ADa British weekly anthology comic. The franchise is centered around Judge Dredda law enforcement and judicial officer in the dystopian future city of Mega-City Onewhich covers most of the east coast of North America.

He is a " street judge ", empowered to summarily arrest, convict, sentence, and execute criminals. When comics editor Pat Mills was developing AD inhe brought in his former writing partner, John Wagnerto develop characters. Wagner had written a Dirty Harry -style "tough cop" story, " One-Eyed Jack ", for Valiantand suggested a character who took that concept to its logical extreme.

Mills had developed a horror strip called Judge Dread after the stage name of British ska and reggae artist Alexander Minto Hughes[2] before abandoning the idea as unsuitable for the new comic; but the name, with the spelling modified to "Dredd" at the suggestion of sub-editor Kelvin Gosnellwas adopted by Wagner.

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The task of visualising the character was given to Carlos Ezquerraa Spanish artist who had worked for Mills before on Battle Picture Weekly. Wagner gave Ezquerra an advertisement for the film Death Raceshowing the character Frankenstein played by David Carradine clad in black leather on a motorbike, as a suggestion of Dredd's appearance.

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Ezquerra added body-armour, zips, and chains, which Wagner initially objected to, [5] commenting that the character looked like a "Spanish pirate. The hardware and cityscapes Ezquerra had drawn were far more futuristic than the near-future setting originally intended; in response, Mills set the story further into the future, [7] on the advice of his art assistant Doug Church. Brother James was considered to be an excellent teacher, but also an excessively strict disciplinarian to the extent that he was considered abusive.

In his blog, Mills detailed the moments of rage for which Brother James had a reputation and his own experience witnessing them. The name Joseph refers to the school. By this stage, Wagner had quit, disillusioned that a proposed buy-out of the new comic by another company, which would have given him and Mills a greater financial stake in the comic, had fallen through.

Their scripts were given to a variety of artists as Mills tried to find a strip which would provide a good introduction to the character. The story chosen to introduce the character was submitted by freelance writer Peter Harris, [note 2] and was extensively re-written by Mills, who added a new ending suggested by Kelvin Gosnell.

The strip debuted in "prog" issue no. Around this time Ezquerra quit and returned to work for Battle. There are conflicting sources about why. Ezquerra says it was because he was angry that another artist had drawn the first published Judge Dredd strip. Wagner soon returned to the character, starting in prog 9. His storyline, " The Robot Wars ", was drawn by a rotating team of artists including Ezquerraand marked the point where Dredd became the most popular character in the comic, a position he has rarely relinquished.

Their stories were less popular with fans, and sales fell. Judge Dredd has also been published in a long-running comic strip — in the Daily Star[21] and briefly in Metro from January to April InDredd was one of 10 British comic characters commemorated in a series of stamps issued by the Royal Mail.

Dredd's first stories take place in the yearyears after its publication date in His regular stories are generally set years after their real-world publication date unless otherwise stated as a flashback or prequel story.

The setting of Judge Dredd is a dystopian future Earth damaged by a series of international conflicts; much of the planet has become radioactive wasteland, and so populations have aggregated in enormous conurbations known as 'mega-cities'.

Within Mega-City One, extensive automation including intelligent robots has rendered the majority of the population unemployed. Mega-City One's population lives in gigantic towers known as City Blockseach holding some 50, people. Eastwood would later play the lead in Dirty Harry — one of the thematic influences by which Judge Dredd was inspired.

A number of stories feature rivalries between different blocks, [30] on many occasions breaking into full-scale gun battles between them [31] such as in the story " Block Mania ". The Judges' powers reflect the difficulty of maintaining order. Mega-City One extends from Boston to Charlotte ; but extended into Florida before the Apocalypse War laid waste to the southern sectors. Following Chaos Day inthe city was reduced to 50 million.

However, immigration quickly increased the population to 72 million by Important Notice: The Drugs. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional.

It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.

Available for Android and iOS devices. Subscribe to Drugs. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Skip to Content.

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California Institute of Technology

For a better experience, please enable JavaScript in your browser before proceeding. Prev 1 … Go to page. Go to page. First Prev of Go to page. Nov 6, Mine test was on Feb 15 and it is still in process. Nov 27, 7 3. Hello, Please update: Oath ceremony date: April 20th, Thank you for your help. IRCC cic. Apr 5, 3, Job Offer Dec 12, 1, Alurra71 said:.

Likely it gives them an idea of when the next ceremonies will be held and perhaps even if falsely gives them hope they will be on the list for an invite? I know that is what I would be interested in, if it were me. Oct 5, 43 Hi, Please update: Oath letter receive today, and the oath date is April Good luck to everyone here. Reactions: leicesterguy. Nov 13, 43 Category Visa Office May 4, 67 Got my oath letter in the mail! Ecas is not updated yet.It was founded as a preparatory and vocational school by Amos G.

The vocational and preparatory schools were disbanded and spun off in and the college assumed its present name in Although Caltech has a strong tradition of practical jokes and pranks, [11] student life is governed by an honor code which allows faculty to assign take-home examinations.

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In addition, there are 56 non-emeritus faculty members as well as many emeritus faculty members who have been elected to one of the United States National Academies4 Chief Scientists of the U. Caltech started as a vocational school founded in Pasadena in by local businessman and politician Amos G. At a time when scientific research in the United States was still in its infancy, George Ellery Halea solar astronomer from the University of Chicagofounded the Mount Wilson Observatory in He joined Throop's board of trustees inand soon began developing it and the whole of Pasadena into a major scientific and cultural destination.

He engineered the appointment of James A. Scherera literary scholar untutored in science but a capable administrator and fund raiser, to Throop's presidency in Scherer persuaded retired businessman and trustee Charles W.

InThroop moved to its current site. Arthur Fleming donated the land for the permanent campus site. Theodore Roosevelt delivered an address at Throop Institute on March 21,and he declared:. I want to see institutions like Throop turn out perhaps ninety-nine of every hundred students as men who are to do given pieces of industrial work better than any one else can do them; I want to see those men do the kind of work that is now being done on the Panama Canal and on the great irrigation projects in the interior of this country—and the one-hundredth man I want to see with the kind of cultural scientific training that will make him and his fellows the matrix out of which you can occasionally develop a man like your great astronomer, George Ellery Hale.

In the same year, a bill was introduced in the California Legislature calling for the establishment of a publicly funded "California Institute of Technology", with an initial budget of a million dollars, ten times the budget of Throop at the time.

The board of trustees offered to turn Throop over to the state, but the presidents of Stanford University and the University of California successfully lobbied to defeat the bill, which allowed Throop to develop as the only scientific research-oriented education institute in southern California, public or private, until the onset of the World War II necessitated the broader development of research-based science education.

With the onset of World War IHale organized the National Research Council to coordinate and support scientific work on military problems. Throop College of Technology, in Pasadena California has recently afforded a striking illustration of one way in which the Research Council can secure co-operation and advance scientific investigation.

This institution, with its able investigators and excellent research laboratories, could be of great service in any broad scheme of cooperation. President Scherer, hearing of the formation of the council, immediately offered to take part in its work, and with this object, he secured within three days an additional research endowment of one hundred thousand dollars. Through the National Research Council, Hale simultaneously lobbied for science to play a larger role in national affairs, and for Throop to play a national role in science.

The new funds were designated for physics research, and ultimately led to the establishment of the Norman Bridge Laboratory, which attracted experimental physicist Robert Andrews Millikan from the University of Chicago in Subsequently, they continued their partnership in developing Caltech. Under the leadership of Hale, Noyes, and Millikan aided by the booming economy of Southern CaliforniaCaltech grew to national prominence in the s and concentrated on the development of Roosevelt's "Hundredth Man".

On November 29,the trustees declared it to be the express policy of the Institute to pursue scientific research of the greatest importance and at the same time "to continue to conduct thorough courses in engineering and pure science, basing the work of these courses on exceptionally strong instruction in the fundamental sciences of mathematics, physics, and chemistry; broadening and enriching the curriculum by a liberal amount of instruction in such subjects as English, history, and economics; and vitalizing all the work of the Institute by the infusion in generous measure of the spirit of research".

Inthe school established a department of geology and hired William Bennett Munrothen chairman of the division of History, Government, and Economics at Harvard Universityto create a division of humanities and social sciences at Caltech.

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Ina division of biology was established under the leadership of Thomas Hunt Morganthe most distinguished biologist in the United States at the time, and discoverer of the role of genes and the chromosome in heredity. Inconstruction of the Palomar Observatory began.

Millikan served as "Chairman of the Executive Council" effectively Caltech's president from toand his influence was such that the Institute was occasionally referred to as "Millikan's School.